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Reagents All chemicals were purchased from Sigma-Aldrich, unless indicated otherwise
In September 2025, the WHO added several GLP-1 drugs, including semaglutide and tirzepatide, to its Model List of Essential Medicines to improve global access to therapies used for diabetes and obesity-related conditions
This structural optimization led to the identification of Compound 32 , a highly potent indane derivative with improved PDE1B inhibitory activity (PDE1B IC 50 : 2.4 nM) (Figure 10)
A significant seborrhea is also observed in acne (172)
The intention is also to allow the peptide to come directly in contact with the gut lining
Beck RW, Connor CG, Mullen DM, Wesley DM, Bergenstal RM
